P-626 Time interval between ovulation triggering and oocyte retrieval and ART outcomes: an updated meta-analysis

Abstract Study question To explore whether prolonged hCG-ovum pickup(hCG-opu) interval improves assisted reproductive technology outcomes. Summary answer The clinical pregnancy rates can be increased by prolonging the hCG-opu interval, which would help develop more reasonable time schedules for fertility centers and patients. What is known already hCG-OPU greatly affects ART success, allows to obtain maximum number of competent mature oocytes while avoiding spontaneous ovulation. There also no consensus regarding optimal between hCG-OPU, some studies had shown that ideal outcomes could obtained when oocyte retrieval was done than 36 h -39 after hCG priming, others have concluded an hours does not improve design, size, duration CENTRAL, CNKI, Cochrane Systematic Reviews, EMBASE, MEDLINE, PUBMED, Web Science up February 7, 2022 were searched reporting associations pickup intervals We prospective or retrospective cohort measuring using as cutoff value short long intervals. A combination following key search terms used: “oocyte retrieval,” “human chorionic gonadotropin,” “interval.” Participants/materials, setting, methods Studies analyzing relationship considered eligible abstract screening. Intervention types included (≤36 h) (>36 in cycles. All based upon only fresh embryo transfers. Data pooled random-effects models. Heterogeneity assessed I 2 statistic. Main results role chance 12 meta-analysis, including five studies, one study, six randomized quasi-randomized controlled trials. groups similar maturation rates, fertilization rate high-quality (OR, 0.69; 95% CI, 0.45–1.06; I2 = 91.1%, OR, 0.88; 0.77–1.0; 44.4% 1.05; 0.95–1.17; 8.6%, respectively). group significantly higher 0.66; 0.45–0.95; 35.4%). miscarriage live birth 1.92; 0.66–5.60; 0.0% 0.50; 0.24–1.04; 0.0%, Limitations, reasons caution Using without patient data represents a potential source bias. selected on relevance, resulting statistical heterogeneity. Despite sensitivity analysis, such heterogeneity sources call interpreting results. Wider implications findings (>36h), support better finding should validated. And if validated multicenter, randomized, trials, implemented programs, Trial registration applicable